Cloned (Comment) | Organism |
---|---|
expression of GRK2-fusion constructs in transgenic flies, expression analysis, overview | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
additional information | lowering Gprk2 levels in the wing disc reduces the expression of Smo targets and causes a phenotype reminiscent of loss of Smo function, phenotype, overview | Drosophila melanogaster |
additional information | generation of a Gprk2 deficiency, phenotype, overview | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Drosophila melanogaster | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smo | Drosophila melanogaster | GPRK2 participates in Hedgehog signaling in Drosophila melanogaster, and plays a key role in the Smo signal transduction pathway, when Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced, overview | ADP + phosphorylated Smo | - |
? | |
additional information | Drosophila melanogaster | Gprk2, a Drosophila member of the G protein-coupled receptor kinases, plays a key role in the Smo, i.e. Smoothened, signal transduction pathway, overview. When Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced. Regulation of Gprk2 expression by Hh signaling in the wing disc, but Gprk2 is also required for Hh signaling in the wing disc, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
gene Gprk2 | - |
Drosophila melanogaster | P32866 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
S2 cell | - |
Drosophila melanogaster | - |
wing | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smo | - |
Drosophila melanogaster | ADP + phosphorylated Smo | - |
? | |
ATP + Smo | GPRK2 participates in Hedgehog signaling in Drosophila melanogaster, and plays a key role in the Smo signal transduction pathway, when Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced, overview | Drosophila melanogaster | ADP + phosphorylated Smo | - |
? | |
additional information | Gprk2, a Drosophila member of the G protein-coupled receptor kinases, plays a key role in the Smo, i.e. Smoothened, signal transduction pathway, overview. When Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced. Regulation of Gprk2 expression by Hh signaling in the wing disc, but Gprk2 is also required for Hh signaling in the wing disc, overview | Drosophila melanogaster | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G protein-coupled receptor regulatory kinase | - |
Drosophila melanogaster |
G protein-coupled receptor regulatory kinase 2 | - |
Drosophila melanogaster |
Gprk2 | - |
Drosophila melanogaster |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Drosophila melanogaster |