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Literature summary for 2.7.11.15 extracted from

  • Desai, A.N.; Salim, S.; Standifer, K.M.; Eikenburg, D.C.
    Involvement of G protein-coupled receptor kinase (GRK) 3 and GRK2 in down-regulation of the alpha2B-adrenoceptor (2006), J. Pharmacol. Exp. Ther., 317, 1027-1035.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in NG-108-15 cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-adrenergic receptor Homo sapiens GRK3 and GRK2 are involved in down-regulation of the alpha2B-adrenoceptor, regulation of the pathway, overview ADP + phosphorylated beta-adrenergic receptor
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BN17 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-adrenergic receptor
-
 Homo sapiens ADP + phosphorylated beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor GRK3 and GRK2 are involved in down-regulation of the alpha2B-adrenoceptor, regulation of the pathway, overview Homo sapiens ADP + phosphorylated beta-adrenergic receptor
-
 ?

Synonyms

Synonyms Comment Organism
GRK2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens