Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | initiates GRK2 membrane translocation | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of GRK2-deficient cells by expression of siRNA leads to increased insulin-induced glycogen synthesis and basal and insulin-stimulated phosphorylation of Ser21 in glycogen synthase kinase-3'alpha, phosphorylation of insulin receptor substrate 1 ia increased in case of GRK2 depletion | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | GRK2 translocation from cytosol to the plasma membrane | Mus musculus | 5829 | - |
membrane | GRK2 membrane translocation is induced by insulin | Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + insulin receptor substrate 1 | Mus musculus | role of GRK2 in insulin receptor IR signaling | ADP + phosphorylated insulin receptor substrate 1 | - |
? | |
additional information | Mus musculus | GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells, regulates basal and insulin-stimulated glycogen synthesis via a post-IR signaling mechanism, and GRK2 may contribute to reduced IR expression and function during chronic insulin exposure | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
FL83B cell | a hepatocyte cell line | Mus musculus | - |
hepatocyte | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + insulin receptor substrate 1 | role of GRK2 in insulin receptor IR signaling | Mus musculus | ADP + phosphorylated insulin receptor substrate 1 | - |
? | |
ATP + insulin receptor substrate 1 | phosphorylation at Ser307 by GRK2 | Mus musculus | ADP + phosphorylated insulin receptor substrate 1 | - |
? | |
additional information | GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells, regulates basal and insulin-stimulated glycogen synthesis via a post-IR signaling mechanism, and GRK2 may contribute to reduced IR expression and function during chronic insulin exposure | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G-protein-coupled receptor kinase 2 | - |
Mus musculus |
GPCR kinase 2 | - |
Mus musculus |
GRK2 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |