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Literature summary for 2.7.11.15 extracted from

  • Peregrin, S.; Jurado-Pueyo, M.; Campos, P.M.; Sanz-Moreno, V.; Ruiz-Gomez, A.; Crespo, P.; Mayor, F.; Murga, C.
    Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK (2006), Curr. Biol., 16, 2042-2047.
    View publication on PubMed
Search for more literature for 2.7.11.15

Protein Variants

Protein Variants Comment Organism
K220R inactive GRK2 mutant Mus musculus
additional information homozygous GRK2-deficient mice are embryonically lethal, heterozygous deficient mice show reduced activity an an altered phenotype, overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + p38 MAP kinase Mus musculus GRK2 inactivates and regulates MAP kinase p38 modulating p38-dependent physiological processes, p38 and GRK2 are localized in a multimolecular complex ADP + phosphorylated p38 MAP kinase
-
 ?
ATP + p38 MAP kinase Mus musculus C57BL/6 GRK2 inactivates and regulates MAP kinase p38 modulating p38-dependent physiological processes, p38 and GRK2 are localized in a multimolecular complex ADP + phosphorylated p38 MAP kinase
-
 ?
additional information Mus musculus GRK2 is essential, and GRK2-deficient mice are embryonically lethal ?
-
 ?
additional information Mus musculus C57BL/6 GRK2 is essential, and GRK2-deficient mice are embryonically lethal ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C75BL/6 mice
-
Mus musculus C57BL/6
-
 C75BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + p38 MAP kinase GRK2 inactivates and regulates MAP kinase p38 modulating p38-dependent physiological processes, p38 and GRK2 are localized in a multimolecular complex Mus musculus ADP + phosphorylated p38 MAP kinase
-
 ?
ATP + p38 MAP kinase phosphorylation at Thr123 located in the docking groove Mus musculus ADP + phosphorylated p38 MAP kinase
-
 ?
ATP + p38 MAP kinase GRK2 inactivates and regulates MAP kinase p38 modulating p38-dependent physiological processes, p38 and GRK2 are localized in a multimolecular complex Mus musculus C57BL/6 ADP + phosphorylated p38 MAP kinase
-
 ?
ATP + p38 MAP kinase phosphorylation at Thr123 located in the docking groove Mus musculus C57BL/6 ADP + phosphorylated p38 MAP kinase
-
 ?
additional information GRK2 is essential, and GRK2-deficient mice are embryonically lethal Mus musculus ?
-
 ?
additional information GRK2 is essential, and GRK2-deficient mice are embryonically lethal Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
GRK2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus