Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | quantitative determination of S-nitrosylation of GRK2 by the biotin-switch assay | Homo sapiens | |
additional information | quantitative determination of S-nitrosylation of GRK2 by the biotin-switch assay | Mus musculus | |
nitric oxide | inhibits GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation | Homo sapiens | |
nitric oxide | inhibits GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation | Mus musculus | |
S-nitrosothiols | inhibit GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation | Homo sapiens | |
S-nitrosothiols | inhibit GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | Mus musculus | the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview | ADP + phosphorylated beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Homo sapiens | the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview | ADP + phosphorylated beta-adrenergic receptor | - |
? | |
ATP + rhodopsin | Mus musculus | - |
ADP + phosphorylated rhodopsin | - |
? | |
ATP + rhodopsin | Homo sapiens | - |
ADP + phosphorylated rhodopsin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
lung | - |
Mus musculus | - |
U2-OS cell | an osteosarcoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview | Mus musculus | ADP + phosphorylated beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview | Homo sapiens | ADP + phosphorylated beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | mapping of S-nitrosylation sites and regulatory locus in GRK2 | Mus musculus | ADP + phosphorylated beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | recombinantly expressed beta-adrenergic receptor in U2-OS cells, mapping of S-nitrosylation sites and regulatory locus in GRK2 | Homo sapiens | ADP + phosphorylated beta-adrenergic receptor | - |
? | |
ATP + rhodopsin | - |
Mus musculus | ADP + phosphorylated rhodopsin | - |
? | |
ATP + rhodopsin | - |
Homo sapiens | ADP + phosphorylated rhodopsin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G-protein-coupled receptor kinase 2 | - |
Mus musculus |
G-protein-coupled receptor kinase 2 | - |
Homo sapiens |
GRK2 | - |
Mus musculus |
GRK2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |