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Literature summary for 2.7.11.15 extracted from
- GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2 (2007), Biochem. Biophys. Res. Commun., 359, 611-615.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transient expression of GRK2 in HEK-293T cells, co-expression with GST-tagged epithelial Na+ channel, and GST-tagged Nedd4 and Nedd4-2 | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Nedd4 | Mus musculus | GRK2 interacts with and phosphorylates the ubiquitin protein ligase Nedd4 preventing the binding to proline-rich motifs present in the C-termini of epithelial Na+ channel subunits and inhibition of the channels, overview | ADP + phosphorylated Nedd4 | - |
? | |
| ATP + Nedd4-2 | Mus musculus | GRK2 interacts with and phosphorylates the ubiquitin protein ligase Nedd4-2 preventing the binding to proline-rich motifs present in the C-termini of epithelial Na+ channel subunits and inhibition of the channels, overview | ADP + phosphorylated Nedd4-2 | - |
? | |
| additional information | Mus musculus | GRK2 plays a role in sodium transport regulation and is involved in the development of essential hypertension, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelium | - |
Mus musculus | - |
| gut | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| salivary gland | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Nedd4 | GRK2 interacts with and phosphorylates the ubiquitin protein ligase Nedd4 preventing the binding to proline-rich motifs present in the C-termini of epithelial Na+ channel subunits and inhibition of the channels, overview | Mus musculus | ADP + phosphorylated Nedd4 | - |
? | |
| ATP + Nedd4 | recombinant GST-tagged wild-type Nedd-4, no activity with Nedd-4 mutant T466A, GRK2 interacts with and phosphorylates the ubiquitin protein ligase Nedd4 at multiple sites, mapping of phosphorylation sites, overview | Mus musculus | ADP + phosphorylated Nedd4 | - |
? | |
| ATP + Nedd4-2 | GRK2 interacts with and phosphorylates the ubiquitin protein ligase Nedd4-2 preventing the binding to proline-rich motifs present in the C-termini of epithelial Na+ channel subunits and inhibition of the channels, overview | Mus musculus | ADP + phosphorylated Nedd4-2 | - |
? | |
| ATP + Nedd4-2 | GRK2 interacts with and phosphorylates the ubiquitin protein ligase Nedd4-2 at multiple sites, mapping of phosphorylation sites, overview | Mus musculus | ADP + phosphorylated Nedd4-2 | - |
? | |
| additional information | GRK2 plays a role in sodium transport regulation and is involved in the development of essential hypertension, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G-protein-coupled receptor kinase 2 | - |
Mus musculus |
| GRK2 | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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