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Literature summary for 2.7.11.15 extracted from

  • Laugwitz, K.L.; Kronsbein, K.; Schmitt, M.; Hoffmann, K.; Seyfarth, M.; Schömig, A.; Ungerer, M.
    Characterization and inhibition of beta-adrenergic receptor kinase in intact myocytes (1997), Cardiovasc. Res., 35, 324-333.
    View publication on PubMed
Search for more literature for 2.7.11.15

Inhibitors

Inhibitors Comment Organism Structure
C-terminus of beta-ARK betaARKmini, inhibits Mesocricetus auratus
C-terminus of beta-ARK betaARKmini, inhibits Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol in unstimulated cells enzyme is mainly located in the cytosol Rattus norvegicus 5829
-
cytosol in unstimulated cells enzyme is mainly located in the cytosol Mesocricetus auratus 5829
-
membrane after beta-AR agonist stimulation beta-ARK is partially translocated to the membranes Rattus norvegicus 16020
-
membrane after beta-AR agonist stimulation beta-ARK is partially translocated to the membranes Mesocricetus auratus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
 Western blot analysis Rattus norvegicus
80000
-
 Western blot analysis Mesocricetus auratus
80000
-
 expected size of native beta-ARK Rattus norvegicus
80000
-
 expected size of native beta-ARK Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-adrenergic receptor Rattus norvegicus agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor Mesocricetus auratus agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor Rattus norvegicus involved in homologous desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor Mesocricetus auratus involved in homologous desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
 ?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
 hamster
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyoblast H9c2 cardiomyolbasts, ATCC CRL 1446 Rattus norvegicus
-
smooth muscle DDT-MF2 smooth muscle cells derived from ductus deferens leiomyosarcoma Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Mesocricetus auratus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor agonist-occupied form of the receptor Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor agonist-occupied form of the receptor Mesocricetus auratus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor involved in homologous desensitization of beta-adrenergic receptor Rattus norvegicus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor involved in homologous desensitization of beta-adrenergic receptor Mesocricetus auratus ADP + phospho-beta-adrenergic receptor
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
ATP
-
 Mesocricetus auratus