Cloned (Comment) | Organism |
---|---|
cDNAs encoding beta-ARK 1, 689 amino acids, and beta-ARK 2, 688 amino acids, are cloned, expressed in COS-7 cells and sequenced | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
additional information | subcellular distribution of beta-ARK 1 and 2 | Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
77000 | - |
beta-ARK 2, Western blot analysis | Rattus norvegicus |
79800 | - |
x * 79800, predicted from the amino acid sequence | Rattus norvegicus |
79900 | - |
x * 79900, predicted from the amino acid sequence | Rattus norvegicus |
82000 | - |
beta-ARK 1, Western blot analysis | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | Rattus norvegicus | general role in the desensitization of synaptic receptors | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Rattus norvegicus | involved in homologous desensitization of beta-adrenergic receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
additional information | Rattus norvegicus | general role in the desensitization of synaptic receptors | ? | - |
? | |
additional information | Rattus norvegicus | general function in desensitizing of many G protein-coupled receptor systems | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P26817 | - |
- |
Rattus norvegicus | P26817 | beta-ARK 1, 2 isoenzymes beta-ARK 1 and 2, adult Sprague-Dawley rats | - |
Rattus norvegicus | P26819 | - |
- |
Rattus norvegicus | P26819 | beta-ARK 2, 2 isoenzymes beta-ARK 1 and 2, adult Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | synapses | Rattus norvegicus | - |
brain | regional and cellular distribution of beta-ARK 1 and 2 in brain | Rattus norvegicus | - |
neuron | beta-ARK 1 and 2 are expressed primarily in neurons distributed throughout the CNS | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | beta2-adrenergic receptor | Rattus norvegicus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Rattus norvegicus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | beta-ARK 1 is more active than beta-ARK 2 | Rattus norvegicus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | beta-AR from hamster lung | Rattus norvegicus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | general role in the desensitization of synaptic receptors | Rattus norvegicus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | involved in homologous desensitization of beta-adrenergic receptor | Rattus norvegicus | ADP + phospho-beta-adrenergic receptor | - |
? | |
additional information | general role in the desensitization of synaptic receptors | Rattus norvegicus | ? | - |
? | |
additional information | general function in desensitizing of many G protein-coupled receptor systems | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 79800, predicted from the amino acid sequence | Rattus norvegicus |
? | x * 79900, predicted from the amino acid sequence | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
beta-adrenergic receptor kinase 1 | - |
Rattus norvegicus |
beta-adrenergic receptor kinase 2 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |