Literature summary for 2.7.11.13 extracted from

Dumont, O.; Mylroie, H.; Bauer, A.; Calay, D.; Sperone, A.; Thornton, C.; Hamdulay, S.S.; Ali, N.; Boyle, J.J.; Choo, J.R.; Samarel, A.M.; Haskard, D.O.; Randi, A.M.; Evans, P.C.; Mason, J.C.
Protein kinase Cepsilon activity induces anti-inflammatory and anti-apoptotic genes via an ERK1/2- and NF-kappaB-dependent pathway to enhance vascular protection (2012), Biochem. J., 447, 193-204.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PKCepsilon	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	depletion of PKCepsilon in human endothelial cells reduces expression of the cytoprotective genes A1, A20 and Bcl-2. Constitutively active PKCepsilon expressed in human endothelial cells increases mRNA and protein levels of these cytoprotective genes, with up-regulation dependent upon ERK1/2 (extracellular-signal regulated kinase 1/2) activation	Homo sapiens
physiological function	PKCepsilon plays an important role as an upstream regulator of endothelial cytoprotection through both the specific induction of protective genes, as well as suppression of pro-inflammatory responses	Homo sapiens

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Release 2023.1 (January 2023)