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Literature summary for 2.7.11.13 extracted from

  • Jiang, H.; Cheng, D.; Liu, W.; Peng, J.; Feng, J.
    Protein kinase C inhibits autophagy and phosphorylates LC3 (2010), Biochem. Biophys. Res. Commun., 395, 471-476.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
phorbol 12-myristate-13-acetate activation of protein kinase C significantly attenuates starvation- or rapamycin-induced LC3 processing. Activation of protein kinase C inhibits autophagy Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
bisindolylmaleimide I PKC inhibitors induce LC3 processing and autophagosome formation. Inhibition of protein kinase C increased autophagy Rattus norvegicus
rottlerin PKC inhibitors induce LC3 processing and autophagosome formation. Inhibition of protein kinase C increased autophagy Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone
-
 Rattus norvegicus ADP + phosphorylated histone
-
 ?
ATP + LC3
-
 Rattus norvegicus ADP + phosphorylated LC3
-
 ?

Synonyms

Synonyms Comment Organism
PKC
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus

General Information

General Information Comment Organism
physiological function activation of protein kinase C significantly attenuates starvation- or rapamycin-induced LC3 processing. The formation of autophagosomes in response to starvation or rapamycin is blocked by PKC activators. PKC inhibitors dramatically induce LC3 processing and autophagosome formation Rattus norvegicus