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Literature summary for 2.7.11.13 extracted from

  • Cai, J.; Crotty, T.M.; Reichert, E.; Carraway, K.L.; Stafforini, D.M.; Topham, M.K.
    Diacylglycerol kinase (delta) and protein kinase Calpha modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8 (2010), J. Biol. Chem., 285, 6952-6959.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
diacylglycerol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Akt PKCalpha inhibits Akt activity that is necessary for proper ubiquitin-specific protease 8 expression Homo sapiens ADP + phosphorylated Akt
-
 ?
ATP + myristoylated alanine-rich C kinase substrate a major PKC substrate Homo sapiens ADP + phosphorylated myristoylated alanine-rich C kinase substrate
-
 ?
additional information PKCalpha modulates the levels of ubiquitinated epidermal growth factor receptor through Akt and ubiquitin-specific protease 8, PKCalpha is necessary for diacylglycerol kinase delta to modulate ubiquitin-specific protease 8 levels Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PKCalpha
-
 Homo sapiens
protein kinase Calpha
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens knockdown of diacylglycerol kinase delta enhances PKCalpha activity up

General Information

General Information Comment Organism
malfunction knockdown of PKCalpha almost completely reduces myristoylated alanine-rich C kinase substrate phosphorylation, indicating that PKCalpha is responsible for the majority of phosphorylated myristoylated alanine-rich C kinase substrate in the cells Homo sapiens