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Literature summary for 2.7.11.13 extracted from

  • Lewis, E.M.; Sergeant, S.; Ledford, B.; Stull, N.; Dinauer, M.C.; McPhail, L.C.
    Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding (2010), J. Biol. Chem., 285, 2959-2967.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
additional information PKC is activated by the addition of 0.03 mg/ml 10:0 1,2-didecanoyl-sn-glycero-3-phosphate, 0.01 mg/ml 1-oleoyl-2-acetoyl-sn-glycerol, and 0.6 mM CaCl2 (no CaCl2 for isoform PKC-delta) for 30 min at 37°C Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO-91-47-67 cell
-
 Cricetulus griseus
-
CHO-K1 cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + mutant protein p22phox(P156Q)
-
 Cricetulus griseus ADP + phosphorylated mutant protein p22phox(P156Q)
-
 ?
ATP + mutant protein p22phox(T132A)
-
 Cricetulus griseus ADP + phosphorylated mutant protein p22phox(T132A)
-
 ?
ATP + NADPH oxidase
-
 Cricetulus griseus ADP + phosphorylated NADPH oxidase
-
 ?
ATP + protein p22phox threonine 147 of protein p22phox is phosphorylated by PKC-alpha and PKC-delta isoforms in vitro Cricetulus griseus ADP + phosphorylated protein p22phox
-
 ?
additional information no phosphorylation of the mutant protein p22phox (T147A) by PKC-alpha or PKC-delta in vitro Cricetulus griseus ?
-
 ?

Synonyms

Synonyms Comment Organism
PKC-alpha isoform Cricetulus griseus
PKC-delta isoform Cricetulus griseus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Cricetulus griseus