Activating Compound | Comment | Organism | Structure |
---|---|---|---|
diacylglycerol | the membrane recruitment and activation of PKCdelta and PKCepsilon is fully dependent on their direct interaction with diacylglycerol generated by adenosine A2a receptor-induced activation of phospholipase C-gamma, through a mechanism requiring both Src and phosphatidylinositol 3-kinase activities | Rattus norvegicus | |
R59949 | increases isofom PKCdelta and PKCepsilon activities in both membrane and cytosolic fractions | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cheletrytrine | complete inhibition at 0.05 mM | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | stimulates activity | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
protein A Sepharose column chromatography | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
HTC cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1 | - |
Rattus norvegicus | ADP + phosphorylated histone H1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKCdelta | isoform | Rattus norvegicus |
PKCepsilon | isoform | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |