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Literature summary for 2.7.11.13 extracted from
- Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta (2005), J. Biol. Chem., 280, 10914-10919.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 12-O-tetradecanoylphorbol-13-acetate | - |
Rattus norvegicus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of isozyme PKCbetaI in HEK-293 cells, and co-expression with dopamine transporter significantly enhancing the amphetamine-stimulated dopamine efflux | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Gö-6976 | IC50 of 2.3-7.9 nM | Rattus norvegicus | |
| LY379196 | highly specific for PKCbeta, inhibits amphetamine-stimulated dopamine efflux in striatum in vivo | Rattus norvegicus | |
| rottlerin | specific for PKCdelta | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | PKC isozymes are divided into groups of calcium-independent and of calcium-dependent isozymes | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | regulation of amphetamine-stimulated dopamine efflux by PKCbetaII, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
several isozymes | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| corpus striatum | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | regulation of amphetamine-stimulated dopamine efflux by PKCbetaII, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKC | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000023 | 0.0000079 | IC50 of 2.3-7.9 nM | Rattus norvegicus | Gö-6976 | |
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