Activating Compound | Comment | Organism | Structure |
---|---|---|---|
arachidonic acid | alone or a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity | Homo sapiens | |
arachidonic acid | slightly enhances PKC zeta activity | Homo sapiens | |
diacylglycerol | plus phosphatidylserine, activates | Homo sapiens | |
gamma-linolenic acid | a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity | Homo sapiens | |
additional information | cannot be activated by phorbol ester treatment of NIH 3T3 cells or insect cells, overexpressing the respective PKC isoenzyme | Homo sapiens | |
phosphatidylserine | plus diacylglycerol, activates | Homo sapiens | |
phosphatidylserine | a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in recombinant baculovirus-infected insect cells | Homo sapiens |
expression in recombinant baculovirus-infected insect cells, overexpression in NIH 3T3 cells or insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | insensitive to PKC inhibitors known to interfere either with the regulatory or the catalytic domain | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activity is independent of Ca2+ | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | constitutive enzyme | ? | - |
? | |
additional information | Homo sapiens | PKC zeta exhibits a constitutive kinase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05129 | - |
- |
Homo sapiens | Q05513 | - |
- |
Purification (Comment) | Organism |
---|---|
partial | Homo sapiens |
partial purification of the PKC-zeta isoenzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + PKC-alpha-derived peptide | in the presence of the classical PKC activators phosphatidylserine/diacylglycerol, PKC alpha phosphorylates a PKC-alpha pseudosubstrate-derived peptide, an epidermal-growth-factor-receptor-derived peptide, histone III-S and myelin basic protein to an equal extent, whilst PKC zeta phosphorylates only the PKC-alpha-derived peptide | Homo sapiens | ADP + phosphorylated PKC-alpha-derived peptide | - |
? | |
additional information | constitutive enzyme | Homo sapiens | ? | - |
? | |
additional information | PKC zeta exhibits a constitutive kinase | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKC-zeta | - |
Homo sapiens |
protein kinase C, gamma type | - |
Homo sapiens |
protein kinase C, zeta type | - |
Homo sapiens |