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Literature summary for 2.7.11.12 extracted from

  • Goncalves, R.L.; Lugnier, C.; Keravis, T.; Lopes, M.J.; Fantini, F.A.; Schmitt, M.; Cortes, S.F.; Lemos, V.S.
    The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue (2009), Eur. J. Pharmacol., 620, 78-83.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
cGMP
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Rp-8-pCPT-cGMPS
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
saphenous vein
-
 Homo sapiens
-
vascular tissue
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
cGMP-dependent protein kinase
-
 Homo sapiens
PKG
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function cGMP-dependent protein kinase is involved in the vasodilation of human saphenous veins Homo sapiens