Any feedback?
Literature summary for 2.7.11.12 extracted from
- Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase (2008), Pflugers Arch., 456, 897-915.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 8-bromo-cGMP | - |
Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | PKG exerts dual functional regulation of neuronal ATP-sensitive potassium channels in a sulfonylurea receptor subunit-dependent manner, which may provide new means of therapeutic intervention for manipulating neuronal excitability and/or survival | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| KT5823 | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
| SH-SY5Y cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Kemptide | - |
Homo sapiens | ADP + Kemptide phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKG | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| cGMP | dependent | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00023 | - |
- |
Homo sapiens | KT5823 | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
