Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-Br-cGMP | - |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | expression of wild-type and mutant human serotonin transporters in HeLa cells and effects on activation through phosphorylation by PKG and cell metabolism, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate Rp-isomer | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens | |
0.00008 | - |
human serotonin transporter T267D/I425V | - |
Homo sapiens | |
0.00011 | - |
human serotonin transporter T267D | - |
Homo sapiens | |
0.00012 | - |
human serotonin transporter T267A/I425V | - |
Homo sapiens | |
0.00013 | - |
human serotonin transporter T267E | - |
Homo sapiens | |
0.00019 | - |
human serotonin transporter T267A | - |
Homo sapiens | |
0.00024 | - |
human serotonin transporter | - |
Homo sapiens | |
0.00026 | - |
human serotonin transporter I425V | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + human serotonin transporter | Homo sapiens | i.e. hSERT, the naturally occuring hSERT mutant I425V is associated with obsessive-compulsive disorder and other neuropsychiatric disorders | ADP + phosphorylated human serotonin transporter | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + human serotonin transporter | i.e. hSERT, the naturally occuring hSERT mutant I425V is associated with obsessive-compulsive disorder and other neuropsychiatric disorders | Homo sapiens | ADP + phosphorylated human serotonin transporter | - |
? | |
ATP + human serotonin transporter | i.e. hSERT, no activity with hSERT mutants T276A or T276D, active with hSERT mutant I425V | Homo sapiens | ADP + phosphorylated human serotonin transporter | - |
? | |
ATP + human serotonin transporter mutant I425V | - |
Homo sapiens | ADP + phosphorylated human serotonin transporter mutant I425V | - |
? | |
ATP + human serotonin transporter mutant T267A | - |
Homo sapiens | ADP + phosphorylated human serotonin transporter mutant T267A | - |
? | |
ATP + human serotonin transporter mutant T267A/I425V | - |
Homo sapiens | ADP + phosphorylated human serotonin transporter mutant T267A/I425V | - |
? | |
ATP + human serotonin transporter mutant T267D | - |
Homo sapiens | ADP + phosphorylated human serotonin transporter mutant T267D | - |
? | |
ATP + human serotonin transporter mutant T267D/I425V | - |
Homo sapiens | ADP + phosphorylated human serotonin transporter mutant T267D/I425V | - |
? | |
ATP + human serotonin transporter mutant T267E | - |
Homo sapiens | ADP + phosphorylated human serotonin transporter mutant T267E | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |