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Literature summary for 2.7.11.12 extracted from

  • Zhang, Y.W.; Gesmonde, J.; Ramamoorthy, S.; Rudnick, G.
    Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder (2007), J. Neurosci., 27, 10878-10886.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
8-Br-cGMP
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information expression of wild-type and mutant human serotonin transporters in HeLa cells and effects on activation through phosphorylation by PKG and cell metabolism, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate Rp-isomer
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Homo sapiens
0.00008
-
human serotonin transporter T267D/I425V
-
Homo sapiens
0.00011
-
human serotonin transporter T267D
-
Homo sapiens
0.00012
-
human serotonin transporter T267A/I425V
-
Homo sapiens
0.00013
-
human serotonin transporter T267E
-
Homo sapiens
0.00019
-
human serotonin transporter T267A
-
Homo sapiens
0.00024
-
human serotonin transporter
-
Homo sapiens
0.00026
-
human serotonin transporter I425V
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + human serotonin transporter Homo sapiens i.e. hSERT, the naturally occuring hSERT mutant I425V is associated with obsessive-compulsive disorder and other neuropsychiatric disorders ADP + phosphorylated human serotonin transporter
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + human serotonin transporter i.e. hSERT, the naturally occuring hSERT mutant I425V is associated with obsessive-compulsive disorder and other neuropsychiatric disorders Homo sapiens ADP + phosphorylated human serotonin transporter
-
?
ATP + human serotonin transporter i.e. hSERT, no activity with hSERT mutants T276A or T276D, active with hSERT mutant I425V Homo sapiens ADP + phosphorylated human serotonin transporter
-
?
ATP + human serotonin transporter mutant I425V
-
Homo sapiens ADP + phosphorylated human serotonin transporter mutant I425V
-
?
ATP + human serotonin transporter mutant T267A
-
Homo sapiens ADP + phosphorylated human serotonin transporter mutant T267A
-
?
ATP + human serotonin transporter mutant T267A/I425V
-
Homo sapiens ADP + phosphorylated human serotonin transporter mutant T267A/I425V
-
?
ATP + human serotonin transporter mutant T267D
-
Homo sapiens ADP + phosphorylated human serotonin transporter mutant T267D
-
?
ATP + human serotonin transporter mutant T267D/I425V
-
Homo sapiens ADP + phosphorylated human serotonin transporter mutant T267D/I425V
-
?
ATP + human serotonin transporter mutant T267E
-
Homo sapiens ADP + phosphorylated human serotonin transporter mutant T267E
-
?

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens