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Literature summary for 2.7.11.12 extracted from
- Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells (2007), J. Immunol., 178, 416-427.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 8-bromo-cGMP | - |
Rattus norvegicus |  |
| cGMP | - |
Rattus norvegicus | |
| formyl-methionyl-leucyl-phenylalanine | - |
Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| KT5823 | in vivo inhibition in leukemia cells causes reduced agonist-stimulated beta-hexosaminidase release and abolishes vesicular fusion with the plasma membrane | Rattus norvegicus | |
| Rp-8-Br-cGMP | in vivo inhibition in leukemia cells causes reduced agonist-stimulated beta-hexosaminidase release and abolishes vesicular fusion with the plasma membrane | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + target membrane SNARe complex | Rattus norvegicus | the enzyme is involved in regulation of degranulation of leukocytes by phosphorylation of target membrane SNARe complex together with the phosphoinositide 3-kinase | ADP + phosphorylated target membrane SNARe complex | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukemia cell | - |
Rattus norvegicus | - |
| leukocyte | - |
Rattus norvegicus | - |
| mast cell | - |
Rattus norvegicus | - |
| RBL-2H3 cell | a basophilic leukemia cell line | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + target membrane SNARe complex | the enzyme is involved in regulation of degranulation of leukocytes by phosphorylation of target membrane SNARe complex together with the phosphoinositide 3-kinase | Rattus norvegicus | ADP + phosphorylated target membrane SNARe complex | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKG | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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