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Literature summary for 2.7.11.12 extracted from

  • Wall, M.E.; Francis, S.H.; Corbin, J.D.; Grimes, K.; Richie-Jannetta, R.; Kotera, J.; Macdonald, B.A.; Gibson, R.R.; Trewhella, J.
    Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase (2003), Proc. Natl. Acad. Sci. USA, 100, 2380-2385.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
cGMP highly dependent on, about 10fold activation, binding and activation mechanisms for wild-type and mutant PKG-Ibeta, modeling, the enzyme elongates upon cGMP binding Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of a PKG-Ibeta deletion mutant DELTA1-52 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information dissociation constants for cGMP binding by wild-type and mutant PKG-Ibeta Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 PKG-Ibeta
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.72
-
 purified monomeric PKG-Ibeta deletion mutant DELTA1-52 Homo sapiens

Subunits

Subunits Comment Organism
monomer structure analysis of PKG-Ibeta deletion mutant DELTA1-52, light scattering Homo sapiens

Synonyms

Synonyms Comment Organism
PKG-I
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens