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Literature summary for 2.7.11.12 extracted from

  • Christensen, E.N.; Mendelsohn, M.E.
    Cyclic GMP-dependent protein kinase Ialpha inhibits thrombin receptor-mediated calcium mobilization in vascular smooth muscle cells (2006), J. Biol. Chem., 281, 8409-8416.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cGMP
-
Homo sapiens
cGMP dependent on Homo sapiens
additional information NO activates the enzyme via increased cGMP level leading to vascular relaxation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
stable expression of PKGIalpha and PKGIbeta in CHO-K1 cells, overexpression of PKGIalpha and PKGIbeta in Co403 cells by adenoviral infection, only expression of PKGIalpha after treatment with 8-bromo-cGMP leads to inhibition of thrombin receptor-mediated Ca2+ mobilization Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cGMP-activated PKGIalpha inhibits thrombin receptor-mediated Ca2+ mobilization in vascular smooth muscle cells, cGMP-activated PKGIbeta causes inhibition in vitro but has nearly no effect in vivo, the thrombin receptor is activated by thrombin receptor activating peptide TRAP, or lysophosphatidic acid, or U4, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Homo sapiens
-
artery
-
Homo sapiens
-
Co-403 cell artery smooth muscle cell line Homo sapiens
-
smooth muscle cell vascular Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cGMP-activated PKGIalpha inhibits thrombin receptor-mediated Ca2+ mobilization in vascular smooth muscle cells, cGMP-activated PKGIbeta causes inhibition in vitro but has nearly no effect in vivo, the thrombin receptor is activated by thrombin receptor activating peptide TRAP, or lysophosphatidic acid, or U4, overview Homo sapiens ?
-
?