Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-bromo-cGMP | - |
Homo sapiens | |
cGMP | dependent on | Homo sapiens | |
additional information | NO activates the enzyme via increased cGMP level leading to vascular relaxation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
stable expression of PKGIalpha and PKGIbeta in CHO-K1 cells, overexpression of PKGIalpha and PKGIbeta in Co403 cells by adenoviral infection, only expression of PKGIalpha after treatment with 8-bromo-cGMP leads to inhibition of thrombin receptor-mediated Ca2+ mobilization | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | cGMP-activated PKGIalpha inhibits thrombin receptor-mediated Ca2+ mobilization in vascular smooth muscle cells, cGMP-activated PKGIbeta causes inhibition in vitro but has nearly no effect in vivo, the thrombin receptor is activated by thrombin receptor activating peptide TRAP, or lysophosphatidic acid, or U4, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Homo sapiens | - |
artery | - |
Homo sapiens | - |
Co-403 cell | artery smooth muscle cell line | Homo sapiens | - |
smooth muscle cell | vascular | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | cGMP-activated PKGIalpha inhibits thrombin receptor-mediated Ca2+ mobilization in vascular smooth muscle cells, cGMP-activated PKGIbeta causes inhibition in vitro but has nearly no effect in vivo, the thrombin receptor is activated by thrombin receptor activating peptide TRAP, or lysophosphatidic acid, or U4, overview | Homo sapiens | ? | - |
? |