Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cGMP | activates both PKGI and PKGII | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression of PKGI and PKGII in UMR106 cells, PKGI expression enhances the glycosynthase kinase-3 phosphorylation to a greater extent than PKGII | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + glycogen synthase kinase-3 | Rattus norvegicus | phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | ADP + phosphorylated glycogen synthase kinase 3 | - |
? | |
additional information | Rattus norvegicus | cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteoblast | - |
Rattus norvegicus | - |
UMR-106 cell | primary psteoblast cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + glycogen synthase kinase-3 | phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | Rattus norvegicus | ADP + phosphorylated glycogen synthase kinase 3 | - |
? | |
ATP + glycogen synthase kinase3 | phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3, substrate phosphorylation site mapping | Rattus norvegicus | ADP + phosphorylated glycogen synthase kinase 3 | - |
? | |
additional information | cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKG | - |
Rattus norvegicus |
PKGI | - |
Rattus norvegicus |
PKGII | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |