Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-pCPT-CGMP | i.e. 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate | Rattus norvegicus | |
cGMP | - |
Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
K482A | site-directed mutagenesis, transfection of the catalytically inactive PKGII mutant inhibits aldosterone production in zona glomerulosa cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | PKGII inhibition inhibits aldosterone production | Rattus norvegicus | |
Rp-8-p-CPT-cGMP | i.e. Rp-8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | PKGII regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | cortex, PKGI | Rattus norvegicus | - |
blood vessel | PKGI | Rattus norvegicus | - |
zona glomerulosa | adrenal, PKGI, expression of PKGII is restricted to adrenal zona glomerulosa cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + steroidogenic acute regulatory protein | i.e. StAR, recombinant GST-tagged substrate expressed in HEK-293 cells, phosphorylation in vitro at Ser55, Ser56, and Ser99 | Rattus norvegicus | ADP + phosphorylated steroidogenic acute regulatory protein | - |
? | |
additional information | PKGII regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGMP-dependent protein kinase type II | - |
Rattus norvegicus |
PKG II | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |