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Literature summary for 2.7.11.12 extracted from

  • Gerzanich, V.; Ivanov, A.; Ivanova, S.; Yang, J.B.; Zhou, H.; Dong, Y.; Simard, J.M.
    Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle (2003), Circ. Res., 93, 805-812.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-APT-cGMP cGKIalpha-selective activator Rattus norvegicus
angiotensin causes an increase in expression of isozyme cGKIbeta, and a decrease in expression of isozyme cGKIalpha Rattus norvegicus
cGMP
-
 Rattus norvegicus
additional information NO activates the enzyme through elevation of cGMP concentration, reduced in hypertensive rats due to a shift in relation of cGKIalpha to cGKIbeta Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
angiotensin causes a decrease in expression of isozyme cGKIalpha, and an increase in expression of isozyme cGKIbeta Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus alternative splicing of PKGI in angiotensin-hypertension, mechanism for nitrate tolerance in vascular smooth muscle ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 normotensive and angiotensin-hypertensive rats, two isoforms cGKIalpha and cGKIbeta of enzyme form cGKI
-

Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Maxi-K channel
-
 Rattus norvegicus ADP + phosphorylated Maxi-K channel
-
 ?
additional information alternative splicing of PKGI in angiotensin-hypertension, mechanism for nitrate tolerance in vascular smooth muscle Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
cGKI
-
 Rattus norvegicus
cGMP-dependent protein kinase I
-
 Rattus norvegicus