Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-Br-cGMP | activates | Homo sapiens | |
cGMP | dependent on | Homo sapiens | |
additional information | enzyme is induced by NO via cGMP | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of GFP-tagged dominant negative mutant type 1-alpha PKG in A-549 cells and of untagged mutant in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the enzyme is inactivated by expression of a dominant negative mutant PKG construct | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is inactivated by expression of a dominant negative mutant type 1alpha PKG construct | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | mainly | Homo sapiens | 5829 | - |
extracellular | dynamic membrane localization | Homo sapiens | - |
- |
plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Rac1 | Homo sapiens | the enzyme activates the recombinant Myc-tagged small GTPase Rac1 in HEK-293 cells leading to activation of PAK1, the enzyme induces phosphorylation of p38 which activates MAPK, regulation, overview | ADP + phosphorylated Rac-1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
type 1alpha PKG | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Rac1 | the enzyme activates the recombinant Myc-tagged small GTPase Rac1 in HEK-293 cells leading to activation of PAK1, the enzyme induces phosphorylation of p38 which activates MAPK, regulation, overview | Homo sapiens | ADP + phosphorylated Rac-1 | - |
? | |
ATP + Rac1 | no activity with Rac-1 mutant T17N | Homo sapiens | ADP + phosphorylated Rac-1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKG | - |
Homo sapiens |
type 1alpha PKG | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |