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Literature summary for 2.7.11.11 extracted from

  • Tu, J.; Lu, L.; Cai, W.; Ballard, H.J.
    cAMP/protein kinase A activates cystic fibrosis transmembrane conductance regulator for ATP release from rat skeletal muscle during low pH or contractions (2012), PLoS ONE, 7, e50157.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
forskolin alone increases activity, which is further increased by the addition of forskolin plus dibutyryl-cAMP and phosphodiesterase inhibitor IBMX Rattus norvegicus
Lactic acid increases intracellular cAMP, pCREB and PKA activity Rattus norvegicus
additional information no intracellular activating effect by sodium lactate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
KT5720
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [cystic fibrosis transmembrane conductance regulator protein] Rattus norvegicus
-
 ADP + [cystic fibrosis transmembrane conductance regulator phosphoprotein]
-
 ?
ATP + [cystic fibrosis transmembrane conductance regulator protein] Rattus norvegicus Sprague-Dawley
-
 ADP + [cystic fibrosis transmembrane conductance regulator phosphoprotein]
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague-Dawley
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
L-6 myoblast cell
-
 Rattus norvegicus
-
myocyte
-
 Rattus norvegicus
-
skeletal muscle soleus muscle Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [cystic fibrosis transmembrane conductance regulator protein]
-
 Rattus norvegicus ADP + [cystic fibrosis transmembrane conductance regulator phosphoprotein]
-
 ?
ATP + [cystic fibrosis transmembrane conductance regulator protein]
-
 Rattus norvegicus Sprague-Dawley ADP + [cystic fibrosis transmembrane conductance regulator phosphoprotein]
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction inhibition of PKA with KT5720 abolishes lactic-acid- or contraction-induced ATP release from muscle Rattus norvegicus
metabolism the cAMP/PKA pathway is involved in the signal transduction pathway for cystic fibrosis transmembrane conductance regulator-regulated ATP release from muscle Rattus norvegicus
physiological function cAMP and PKA are involved in the activation of cystic fibrosis transmembrane conductance regulator, CFTR, during muscle contractions or acidosis. CFTR is involved in the release of ATP from the contracting skeletal muscle in vivo, role of intracellular cAMP in stimulating the increase in extracellular ATP at low pH Rattus norvegicus