Literature summary for 2.7.11.11 extracted from

Pastok, M.W.; Prescott, M.C.; Dart, C.; Murray, P.; Rees, H.H.; Fisher, M.J.
Structural diversity of the cAMP-dependent protein kinase regulatory subunit in Caenorhabditis elegans (2013), Cell. Signal., 25, 168-177.

Search for more literature for 2.7.11.11

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis, PK-A R-subunit exons and introns, modified version of that published in WormBase, overview.Gene models R07E4.6a, R07E4.6b, and R07E4.6q, encoding isoforms A, B, and Q, RT-PCR expression analysis	Caenorhabditis elegans

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	-	single genes encode the catalytic (C) subunit (kin-1), the regulatory (R) subunit (kin-2) and an A-kinase anchor protein (AKAP)	-

Subunits

Subunits	Comment	Organism
dimer	in Caenorhabditis elegans, in addition to tetrameric (R2C2) PK-A holoenzymes, there is also a sub-population of dimeric (RC) PK-A enzymes that are not tethered by AKAPs	Caenorhabditis elegans
More	the enzyme contains the catalytic C subunit, the regulatory R subunit and an A-kinase anchor protein encoded by single genes kin-1, kin-2, and AKAP, respectively. R-subunit isoforms containing exon B- or exon Q-encoded polypeptide sequences lack the dimerisation/docking domains conventionally seen in R-subunits, and are unlikely to participate in the formation of tetrameric PK-A holoenzymes and are, additionally, unlikely to interact with AKAP(s)	Caenorhabditis elegans
tetramer	in Caenorhabditis elegans, in addition to tetrameric (R2C2) PK-A holoenzymes, there is also a sub-population of dimeric (RC) PK-A enzymes that are not tethered by AKAPs	Caenorhabditis elegans

Synonyms

Synonyms	Comment	Organism
PK-A	-	Caenorhabditis elegans
protein kinase A	-	Caenorhabditis elegans

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)