Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DU-145 cell | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
prostate cancer cell line | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
cyclic AMP-dependent protein kinase A | - |
Homo sapiens |
PKA | - |
Homo sapiens |
PKA RIalpha | regulatory subunit I alpha of PKA | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
cAMP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | combined inhibition of the androgen receptor and the regulatory subunit I alpha of PKA with small interference RNAs significantly increases the growth-inhibitory and proapoptotic effects of androgen receptor knockdown. Downregulating PKA RIalpha is sufficient to inhibit PKA signaling and also impairs androgen receptor expression and activation. Depletion of PKA RIalpha also potentiates the antiproliferative effect of the antiandrogen bicalutamide in androgen-sensitive LNCaP cells | Homo sapiens |