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Literature summary for 2.7.11.11 extracted from

  • Hochbaum, D.; Hong, K.; Barila, G.; Ribeiro-Neto, F.; Altschuler, D.L.
    Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis (2008), J. Biol. Chem., 283, 4464-4468.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
forskolin
-
 Rattus norvegicus
N6-benzoyladenosine-3',5'-cyclic monophosphate PKA-specific cAMP analog Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
H-89
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus exchange protein activated by cAMP acts synergistically with PKA in cAMP-mediated mitogenesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PCCL-3 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cAMP-response element-binding protein
-
 Rattus norvegicus ADP + phosphorylated cAMP-response element-binding protein
-
 ?
additional information exchange protein activated by cAMP acts synergistically with PKA in cAMP-mediated mitogenesis Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
PKA
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
cAMP dependent Rattus norvegicus