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Literature summary for 2.7.11.11 extracted from

  • Grosse, C.; Heinekamp, T.; Kniemeyer, O.; Gehrke, A.; Brakhage, A.A.
    Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus (2008), Appl. Environ. Microbiol., 74, 4923-4933.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
the catalytic subunit of PKA (pkaC1) is overexpressed in Aspergillus fumigatus, strains overexpressing pkaC1 show high PKA activity, reduced growth, sporulation deficiency, and formation of a dark pigment in the mycelium Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Aspergillus fumigatus elevated PKA activity results in activation of stress-associated proteins and of enzymes involved in protein biosynthesis and glucose catabolism, in contrast, proteins which are involved in nucleotide and amino acid biosynthesis are downregulated ?
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 ?

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Kemptide
-
 Aspergillus fumigatus ADP + Kemptide phosphate
-
 ?
additional information elevated PKA activity results in activation of stress-associated proteins and of enzymes involved in protein biosynthesis and glucose catabolism, in contrast, proteins which are involved in nucleotide and amino acid biosynthesis are downregulated Aspergillus fumigatus ?
-
 ?

Synonyms

Synonyms Comment Organism
PKA
-
 Aspergillus fumigatus
protein kinase A
-
 Aspergillus fumigatus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Aspergillus fumigatus