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Literature summary for 2.7.11.11 extracted from
- gamma-Hydroxybutyrate induces cyclic AMP-responsive element-binding protein phosphorylation in mouse hippocampus: An involvement of GABAB receptors and cAMP-dependent protein kinase activation (2006), Neuroscience, 141, 269-275.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | gamma-hydroxybutyrate induces the enzyme in the hippocampus, the phosphorylation activity is increased via GABAB receptors, but a desensitization of the signaling pathway occurs after repeated administration of gamma-hydroxybutyrate, overview | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| H-89 | i.e. N-[2-((4-bromocinnamyl)amino)ethyl]5-isoquinolinesulfonamide, as hydrochloride | Mus musculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + cAMP-responsive element binding protein | Mus musculus | the enzyme as well as GABAB receptors are involved in induction of cAMP-responsive element binding protein phosphorylation in hippocampus by gamma-hydroxybutyrate, overview | ADP + phosphorylated cAMP-responsive element binding protein | - |
? | |
| ATP + cAMP-responsive element binding protein | Mus musculus C57BL/6 | the enzyme as well as GABAB receptors are involved in induction of cAMP-responsive element binding protein phosphorylation in hippocampus by gamma-hydroxybutyrate, overview | ADP + phosphorylated cAMP-responsive element binding protein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57/BL6 mice | - |
| Mus musculus C57BL/6 | - |
C57/BL6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| hippocampus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + cAMP-responsive element binding protein | i.e. CREB | Mus musculus | ADP + phosphorylated cAMP-responsive element binding protein | - |
? | |
| ATP + cAMP-responsive element binding protein | the enzyme as well as GABAB receptors are involved in induction of cAMP-responsive element binding protein phosphorylation in hippocampus by gamma-hydroxybutyrate, overview | Mus musculus | ADP + phosphorylated cAMP-responsive element binding protein | - |
? | |
| ATP + cAMP-responsive element binding protein | i.e. CREB | Mus musculus C57BL/6 | ADP + phosphorylated cAMP-responsive element binding protein | - |
? | |
| ATP + cAMP-responsive element binding protein | the enzyme as well as GABAB receptors are involved in induction of cAMP-responsive element binding protein phosphorylation in hippocampus by gamma-hydroxybutyrate, overview | Mus musculus C57BL/6 | ADP + phosphorylated cAMP-responsive element binding protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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