Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-bromo-cAMP | stimulates | Homo sapiens | |
cAMP | - |
Homo sapiens | |
forskolin | stimulates the cAMP-dependent enzyme | Homo sapiens | |
isoproterenol | stimulates | Homo sapiens | |
additional information | under mild oxidizing conditions, or short exposure to oxidants, forskolin-stimulated PKA activity is enhanced | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
H89 | - |
Homo sapiens | |
additional information | PKA is inhibited by oxidation via either glutathionylation of Cys199 in the activation loop, or the formation of an internal disulfide bond between Cys199 and Cys343 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
additional information | in HeLa cells PKA activity follows a biphasic response to thiol oxidation, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation, in HeLa cells PKA activity follows a biphasic response to thiol oxidation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + kemptide | - |
Homo sapiens | ADP + phospho-kemptide | - |
? | |
additional information | redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation, in HeLa cells PKA activity follows a biphasic response to thiol oxidation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKA | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |