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Literature summary for 2.7.11.11 extracted from

  • Humphries, K.M.; Pennypacker, J.K.; Taylor, S.S.
    Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation (2007), J. Biol. Chem., 282, 22072-22079.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cAMP stimulates Homo sapiens
cAMP
-
Homo sapiens
forskolin stimulates the cAMP-dependent enzyme Homo sapiens
isoproterenol stimulates Homo sapiens
additional information under mild oxidizing conditions, or short exposure to oxidants, forskolin-stimulated PKA activity is enhanced Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H89
-
Homo sapiens
additional information PKA is inhibited by oxidation via either glutathionylation of Cys199 in the activation loop, or the formation of an internal disulfide bond between Cys199 and Cys343 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens
additional information in HeLa cells PKA activity follows a biphasic response to thiol oxidation, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation, in HeLa cells PKA activity follows a biphasic response to thiol oxidation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + kemptide
-
Homo sapiens ADP + phospho-kemptide
-
?
additional information redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation, in HeLa cells PKA activity follows a biphasic response to thiol oxidation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PKA
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens