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Literature summary for 2.7.11.11 extracted from
- Catalytic subunit of cAMP-dependent protein kinase from a catch muscle of the bivalve mollusk Mytilus galloprovincialis: purification, characterization, and phosphorylation of muscle proteins (2006), Arch. Biochem. Biophys., 450, 133-140.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| inhibitor peptide PKI5-24 | inhibits the catalytic subunit | Mytilus galloprovincialis | |
| additional information | the two isoforms of the regulatory subunit inhibit the catalytic subunit | Mytilus galloprovincialis |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 37700 | - |
catalytic subunit, gel filtration | Mytilus galloprovincialis |
| 40000 | - |
1 * 40000, catalytic subunit, SDS-PAGE | Mytilus galloprovincialis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + actin | Mytilus galloprovincialis | low activity | ADP + phosphorylated actin | - |
? |  |
| ATP + catchin | Mytilus galloprovincialis | low activity | ADP + phosphorylated catchin | - |
? | |
| ATP + paramyosin | Mytilus galloprovincialis | low activity | ADP + phosphorylated paramyosin | - |
? | |
| ATP + twitchin | Mytilus galloprovincialis | - |
ADP + phosphorylated twitchin | - |
? | |
| additional information | Mytilus galloprovincialis | PKA plays a crucial role in the release of the catch state of molluskan muscles, mechanism, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mytilus galloprovincialis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from posterior adductor muscle by anion exchange chromatography, ultrafiltration, and gel filtration | Mytilus galloprovincialis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| posterior adductor muscle | - |
Mytilus galloprovincialis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + actin | low activity | Mytilus galloprovincialis | ADP + phosphorylated actin | - |
? | |
| ATP + catchin | low activity | Mytilus galloprovincialis | ADP + phosphorylated catchin | - |
? | |
| ATP + kemptide | - |
Mytilus galloprovincialis | ADP + phospho-kemptide | - |
? | |
| ATP + paramyosin | low activity | Mytilus galloprovincialis | ADP + phosphorylated paramyosin | - |
? | |
| ATP + twitchin | - |
Mytilus galloprovincialis | ADP + phosphorylated twitchin | - |
? | |
| ATP + twitchin | a high molecular mass protein associated with thick filaments, high activity | Mytilus galloprovincialis | ADP + phosphorylated twitchin | - |
? | |
| additional information | PKA plays a crucial role in the release of the catch state of molluskan muscles, mechanism, overview | Mytilus galloprovincialis | ? | - |
? | |
| additional information | no activity with myosin heavy chain and tropomyosin | Mytilus galloprovincialis | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 40000, catalytic subunit, SDS-PAGE | Mytilus galloprovincialis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Mytilus galloprovincialis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mytilus galloprovincialis | |
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Release 2023.1 (January 2023)
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