Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cAMP | dependent on | Homo sapiens | |
additional information | forskolin induces PKA activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
H-89 | strong inhibition | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone deacetylase 8 | Homo sapiens | FLAG-tagged class 1 histone deacetylase HDAC8 expressed in HeLa cells via adenovirus infection, phosphorylation at Ser39 reduces the enzyme activity of HDAC8, hyperphosphorylation inhibits the enzyme | ADP + phosphorylated histone deacetylase 8 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone deacetylase 8 | FLAG-tagged class 1 histone deacetylase HDAC8 expressed in HeLa cells via adenovirus infection, phosphorylation at Ser39 reduces the enzyme activity of HDAC8, hyperphosphorylation inhibits the enzyme | Homo sapiens | ADP + phosphorylated histone deacetylase 8 | - |
? | |
ATP + histone deacetylase 8 | class 1 histone deacetylase HDAC8, recombinantly expressed FLAG-tagged GST-fusion substrate protein, Ser39 is the major phosphorylation site, low activity with HDAC8 mutant S39A | Homo sapiens | ADP + phosphorylated histone deacetylase 8 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cyclic AMP-dependent protein kinase A | - |
Homo sapiens |
PKA | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |