Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cAMP | dependent on | Mus musculus | |
additional information | phosphorylation of CBP by PKA type I is induced by forskolin and ethanol, inhibition of MAPK activates the PKA type I | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | activated type I PKA is not translocated to the nucleus | Mus musculus | 5737 | - |
nucleus | activated type II PKA is translocated to the nucleus | Mus musculus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + CRE-binding protein | Mus musculus | i.e. CREB, a transcription factor, activition by type I PKA | ADP + CRE-binding phosphoprotein | - |
? | |
ATP + CREB-binding protein | Mus musculus | i.e. CBP, activition by type II PKA | ADP + CREB-binding phosphoprotein | - |
? | |
additional information | Mus musculus | PKA type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK, regulation overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
2 types of PKA | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NG-108-15 cell | neuroblastoma x glioma hybrid cell | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + CRE-binding protein | i.e. CREB, a transcription factor, activition by type I PKA | Mus musculus | ADP + CRE-binding phosphoprotein | - |
? | |
ATP + CREB-binding protein | i.e. CBP, activition by type II PKA | Mus musculus | ADP + CREB-binding phosphoprotein | - |
? | |
additional information | PKA type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK, regulation overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cAMP-dependent protein kinase type I | - |
Mus musculus |
type I PKA | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |