Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cAMP | dependent on | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | the enzyme binds to and colocalizes with the kinase-anchoring protein gravin in the neuronal cortex membrane which is enriched in the inner peripheral cortex in close proximity to the plasma membrane | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme interacts with the neuron cortex membrane protein gravin via Ca2+-independent binding to the regulatory RII enzyme subunit, gravin provides a platform to localize kinases, besides PKA also PKCalpha and PKCbetaII, in an isozyme-specific and activation-dependent manner at specific sites in neurons, gravin is strongly upregulated in cells during differentiation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NT2-N cell | precursor-like neuronal cells and differentiated NT2 cells, model neurons | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme interacts with the neuron cortex membrane protein gravin via Ca2+-independent binding to the regulatory RII enzyme subunit, gravin provides a platform to localize kinases, besides PKA also PKCalpha and PKCbetaII, in an isozyme-specific and activation-dependent manner at specific sites in neurons, gravin is strongly upregulated in cells during differentiation, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
oligomer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PKA | - |
Homo sapiens |