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Literature summary for 2.7.11.11 extracted from

  • Soulsby, M.D.; Wojcikiewicz, R.J.H.
    The type III inositol 1,4,5-trisphosphate receptor is phosphorylated by cAMP-dependent protein kinase at three sites (2005), Biochem. J., 392, 493-497.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cAMP activates Homo sapiens
additional information forskolin induces enzyme activity Homo sapiens
prostaglandin E1 activates Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + type III inositol 1,4,5-trisphosphate receptor Homo sapiens i.e. IP3 receptor, recombinantly expressed in HEK cells, forms tetrameric Ca2+ channels in the endoplasmic reticulum ADP + phosphorylated type III inositol 1,4,5-trisphosphate receptor
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell embryonic kidney cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + type III inositol 1,4,5-trisphosphate receptor i.e. IP3 receptor, recombinantly expressed in HEK cells, forms tetrameric Ca2+ channels in the endoplasmic reticulum Homo sapiens ADP + phosphorylated type III inositol 1,4,5-trisphosphate receptor
-
 ?
ATP + type III inositol 1,4,5-trisphosphate receptor phosphorylation sites are Ser916, Ser934, and Ser1832, Ser934 is the most susceptible site Homo sapiens ADP + phosphorylated type III inositol 1,4,5-trisphosphate receptor
-
 ?

Synonyms

Synonyms Comment Organism
PKA
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens