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Literature summary for 2.7.11.10 extracted from

  • Xie, Y.; Li, Y.; Peng, X.; Peng, X.; Henderson, F.; Deng, L.; Chen, N.
    Ikappa B kinase alpha involvement in the development of nasopharyngeal carcinoma through a NF-kappaB-independent and ERK-dependent pathway (2013), Oral Oncol., 49, 1113-1120.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [IkappaB protein] Homo sapiens
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
nasopharyngeal carcinoma cell
-
 Homo sapiens
-
NP-69-SV40T cell
-
 Homo sapiens
-
SUNE-1 cell
-
 Homo sapiens
-
SUNE-1-5-8F cell
-
 Homo sapiens
-
SUNE-1-6-10B cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?

Synonyms

Synonyms Comment Organism
Ikappa B kinase alpha
-
 Homo sapiens
IKKalpha
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is underexpressed in highly invasive SUNE-1-5-8F cells compared with non-invasive cells (SUNE-1 and SUNE-6-10B) down

General Information

General Information Comment Organism
physiological function increase in enzyme expression suppresses the progression of nasopharyngeal carcinoma through a nuclear factor-kappaB-independent and extracellular signal-regulated kinase-dependent pathway Homo sapiens