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Literature summary for 2.7.11.10 extracted from
- IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver (2008), Proc. Natl. Acad. Sci. USA, 105, 9733-9738.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | results reveal a novel function of the two IkappaB kinases in cooperatively regulating liver immune homeostasis and bile duct integrity and suggest that IKK signaling may be implicated in human biliary diseases | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | knock-out mice are generated lacking IKK1, IKK2, NEMO(IKKgamma), or both IKK1 and IKK2 in liver parenchymal cells: IKK1 and IKK2 ablation, sensitizes the liver to in vivo LPS challenge, uncovering a redundant function of the two IkappaB kinases in mediating canonical NF-kappaB signaling in hepatocytes and protecting the liver from TNF-induced failure. Knock out mice with combined ablation of IKK1 and IKK2 or IKK1 and NEMO spontaneously develop severe jaundice and fatal cholangitis characterized by inflammatory destruction of small portal bile ducts | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IKK1 | - |
Mus musculus |
| IKKalpha | - |
Mus musculus |
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Release 2023.1 (January 2023)
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