Literature summary for 2.7.11.10 extracted from

Dan, H.C.; Baldwin, A.S.
Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt (2008), J. Immunol., 180, 7582-7589.

Search for more literature for 2.7.11.10

Protein Variants

Protein Variants	Comment	Organism
additional information	analysis of IKKalpha and IKKbeta knockout cells shows that IKK alpha is the critical IKK subunit in controlling insulin-induced interaction with mTOR	Homo sapiens
additional information	in HEK293 cells, knockdown of IKK alpha suppresses TNF-induced mTOR activation by greater that 50%, knockdown of IKKbeta has less of an effect	Homo sapiens
additional information	using IKKbeta MCF7 knockout cells it is shown that in MCF7 cells TNF does not activate Akt and requires IKKbeta to activate mTOR	Mus musculus
additional information	using siRNA to IKKalpha it is shown that IKKalpha is required for efficient induction of mTOR activation in response to insulin or TNF. Knockout of IKKalpha significantly reduces insulin- or TNF-induced activation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15111	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
IKKalpha	-	Mus musculus
IKKalpha	-	Homo sapiens

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Release 2023.1 (January 2023)