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Literature summary for 2.7.11.10 extracted from

  • Mukherjee, S.; Negi, V.S.; Keitany, G.; Tanaka, Y.; Orth, K.
    In vitro activation of the IkappaB kinase complex by human T-cell leukemia virus type-1 Tax (2008), J. Biol. Chem., 283, 15127-15133.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.10

Activating Compound

Activating Compound Comment Organism Structure
human leukemia virus type-1 TAX TAX is binding to and activating the IKK complex. A sustained activation of the Tax-mediated activation of the NFkappaB pathway is dependent on an intact Hsp90-IKK complex Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
YopJ effector protein YopJ from Yersinia pestis inhibits MAPK kinase and IKK activation by acetylating the conserved serine and threonine residues in the activation loop of the kinase. Furthermore, YopJ inhibits Tax-mediated IkappaB phosphorylation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein human leukemia virus type-1 TAX-mediates IkappaB phosphorylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + IkappaB protein
-
 Homo sapiens ADP + IkappaB phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
IkappaB kinase
-
 Homo sapiens
IKK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Homo sapiens