Literature summary for 2.7.11.10 extracted from

Lo, Y.C.; Maddineni, U.; Chung, J.Y.; Rich, R.L.; Myszka, D.G.; Wu, H.
High-affinity interaction between IKKbeta and NEMO (2008), Biochemistry, 47, 3109-3116.

Search for more literature for 2.7.11.10

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli as a His-tagged fusion protein	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
DELTA1-640	deletion mutant containing residues 640-756, which contains the entire C-terminal region after the HLH domain, interacts well with NEMO	Homo sapiens
DELTA1-680	deletion mutant wich stably interacts with NEMO	Homo sapiens
DELTA1-705	deletion mutant comprising just the predicted alpha-helical and coiled-coil region and the NEMO binding domain (NPD) residues 734-745 is sufficient for a stable interaction with NEMO	Homo sapiens
DELTA1-734	deletion mutant containing only the 11-residues of the NEMO-binding region (NBD) is not sufficient for interaction with NEMO	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14920	-	-

Purification (Commentary)

Purification (Comment)	Organism
using Ni-NTA-chromatography	Homo sapiens

Synonyms

Synonyms	Comment	Organism
IKKbeta	-	Homo sapiens

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Release 2023.1 (January 2023)