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Literature summary for 2.7.11.10 extracted from

  • Tenoever, B.R.; Ng, S.L.; Chua, M.A.; McWhirter, S.M.; Garcia-Sastre, A.; Maniatis, T.
    Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity (2007), Science, 315, 1274-1278.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information virus-inducible expression of IKKepsilon, IKKepsilon is activated by IFNbeta Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
IKKepsilon expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information disruption of Ikbke-/-, the gene encoding IKKepsilon, results in a complete loss of the kinase in both mice and embryonic fibroblasts, generation of mice lacking IKKepsilon, the mice produce normal amounts of IFNbeta, but are hypersusceptible to viral infection because of a defect in the IFN signaling pathway, phenotype, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus IKKepsilon, i.e. IKKi, is implicated in virus induction of interferon-beta, IFNbeta, and development of immunity, IKKepsilon functions in a redundant role to its ubiquitous counterpart, TBK1, in the activation of IRF3 and IRF7 ex vivo, IKKe determines ISGF3 binding specificity, regulaiton, overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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gene Ikbke
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast mouse embryonic fibroblasts, MEF Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IKKepsilon, i.e. IKKi, is implicated in virus induction of interferon-beta, IFNbeta, and development of immunity, IKKepsilon functions in a redundant role to its ubiquitous counterpart, TBK1, in the activation of IRF3 and IRF7 ex vivo, IKKe determines ISGF3 binding specificity, regulaiton, overview Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
IKK-related kinase
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Mus musculus
IKKepsilon
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Mus musculus
IKKi
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Mus musculus
inhibitor of nuclear factor kB kinase-related kinase
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Mus musculus
TANK-binding kinase 1
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Mus musculus
TBK1
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Mus musculus