Application | Comment | Organism |
---|---|---|
medicine | IKKlapha may represent a specific target for treatment of ErbB2-positive breast cancer | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | IkkalphaAA/AA 'knockin' mice, in which activation of IKKalpha is prevented by replacement of activation loop serines with alanines, exhibit delayed mammary gland growth during pregnancy, because IKKalpha activity is required for cyclin D1 induction and proliferation of lobuloalveolar epithelial cells, overview, retarded tumor development in response to either 7,12-dimethylbenzaanthracene or the ErbB2/Her2 transgene but had no effect on MMTV-v-Haras-induced cancer, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | IKKalpha is not only a regulator of mammary epithelial proliferation, but is also an important contributor to ErbB2-induced oncogenesis, providing signals that maintain mammary tumor-initiating cells, IKKalpha activity is required for cyclin D1 induction and proliferation of lobuloalveolar epithelial cells, and is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Mus musculus | - |
breast cancer cell | - |
Mus musculus | - |
epithelium | - |
Mus musculus | - |
mammary gland | lobuloalveolar epithelial cell | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | IKKalpha is not only a regulator of mammary epithelial proliferation, but is also an important contributor to ErbB2-induced oncogenesis, providing signals that maintain mammary tumor-initiating cells, IKKalpha activity is required for cyclin D1 induction and proliferation of lobuloalveolar epithelial cells, and is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IKKalpha | - |
Mus musculus |