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Literature summary for 2.7.11.10 extracted from
- IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9 (2006), Nature, 440, 949-953.
Application
| Application | Comment | Organism |
|---|---|---|
| molecular biology | IKK-alpha is a potential target for manipulating TLR-induced IFN-alpha production | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | TLR7/9-induced IFN-alpha production is severely impaired in constructed IKK-alpha-deficient plasmacytoid dendritic cells, whereas inflammatory cytokine induction is decreased but still occurrs, kinase-deficient IKK-alpha inhibits the ability of MyD88 to activate the Ifna promoter in synergy with IRF-7, expression of kinase-deficient IKK-alpha does not affect IRF-7-mediated promoter activation, but inhibits the enhancing effects ofMyD88 | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9, but IKK-a is dispensable for a cytoplasmic RNA helicase RIG-I-dependent cytosolic pathway-induced production of IFN-alpha in MEF cells, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| dendritic cell | partly derived from bone marrow | Mus musculus | - |
| fibroblast | mouse embryonic fibroblasts, MEF | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9, but IKK-a is dispensable for a cytoplasmic RNA helicase RIG-I-dependent cytosolic pathway-induced production of IFN-alpha in MEF cells, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IkappaB kinase-alpha | - |
Mus musculus |
| IKK-alpha | - |
Mus musculus |
| Ikka | - |
Mus musculus |
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