Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | cytokine-induced activation of IKK, e.g. by TNFalpha, required for NFkappaB activation, leads to rapid degradation of IkappaB | Homo sapiens | |
additional information | TNF-alpha induced association of IKK-alpha with p65 and CBP | Mus musculus | |
TNFalpha | activates histone H3 phosphorylation activity, TNFalpha-induced activation of IKK-beta but not IKK-alpha leads to rapid NFkappaB activation and subsequent degradation of IkappaB | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of Myc-tagged IKK-alpha or IKK-beta in embryonic fibroblasts MEF cell line | Mus musculus |
expression of Myc-tagged IKK-alpha or IKK-beta in mouse embryonic fibroblasts MEF cell line | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | IKK-beta and IKK-alpha | Mus musculus | 5737 | - |
cytoplasm | IKK-beta and IKK-alpha | Homo sapiens | 5737 | - |
nucleus | IKK-alpha | Mus musculus | 5634 | - |
nucleus | IKK-alpha | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [histone H3 protein] | Mus musculus | histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression | ADP + [histone H3 phosphoprotein] | - |
? | |
ATP + [histone H3 protein] | Homo sapiens | histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression | ADP + [histone H3 phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | Mus musculus | - |
ADP + [IkappaB phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | Homo sapiens | - |
ADP + [IkappaB phosphoprotein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
IKK-alpha and IKK-beta | - |
Mus musculus | - |
IKK-alpha and IKK-beta | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Mus musculus | - |
fibroblast | embryonic | Mus musculus | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [histone H3 protein] | - |
Homo sapiens | ADP + [histone H3 phosphoprotein] | - |
? | |
ATP + [histone H3 protein] | histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression | Mus musculus | ADP + [histone H3 phosphoprotein] | - |
? | |
ATP + [histone H3 protein] | histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression | Homo sapiens | ADP + [histone H3 phosphoprotein] | - |
? | |
ATP + [histone H3 protein] | phosphorylation at Ser10 by IKK-alpha | Mus musculus | ADP + [histone H3 phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | - |
Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | - |
Homo sapiens | ADP + [IkappaB phosphoprotein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IKK | - |
Mus musculus |
IKK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |