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Literature summary for 2.7.11.10 extracted from
- IKKbeta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide (2003), J. Immunol., 170, 5630-5635.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | lipopolysaccharides from Escherichia coli induce enzyme activity versus RelA/p65 and NFkappaB activation in vivo, induction is not inhibited by LY294002, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Mus musculus | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [IkappaB protein] | Mus musculus | - |
ADP + [IkappaB phosphoprotein] | - |
? |  |
| ATP + [RelA/p65 protein] | Mus musculus | - |
ADP + [RelA/p65 phosphoprotein] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
| fibroblast | - |
Mus musculus | - |
| macrophage | - |
Mus musculus | - |
| MEF cell | - |
Mus musculus | - |
| monocyte | - |
Mus musculus | - |
| RAW-264.7 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [IkappaB protein] | - |
Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
| ATP + [IkappaBalpha protein] | phosphorylation on Ser32 and Ser36 | Mus musculus | ADP + [IkappaBalpha phosphoprotein] | - |
? | |
| ATP + [RelA/p65 protein] | - |
Mus musculus | ADP + [RelA/p65 phosphoprotein] | - |
? | |
| ATP + [RelA/p65 protein] | phosphorylation on Ser536 of the transactivation domain, dependent on lipopolysaccharide-induction, but not on Akt or p65 | Mus musculus | ADP + [RelA/p65 phosphoprotein] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IKK | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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