Protein Variants | Comment | Organism |
---|---|---|
additional information | IKKbeta-deficient B-cells are impaired in mitogenic responses to lipopolysaccharides, anti-CD40, and anti-IgM, and show high reduction of all peripheral B-cell subsets due to associated defects in cell survival | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | IKKbeta is required for regulation of NFkappaB activity and peripheral B cell survival and proliferation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 wild-type mice or murine strains deficient in either subunits IKKalpha, IKKbeta, or IKKgamma, overview | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-cell | peripheral | Mus musculus | - |
B-lymphocyte | peripheral | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | IKKbeta is required for regulation of NFkappaB activity and peripheral B cell survival and proliferation | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and regulatory IKKgamma | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
IKK complex | - |
Mus musculus |