Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of IKKalpha-deficient and of IKKbeta-deficient mice and BM cell mutants, the mutants show defective osteoclastogenesis, wild-type osteoblasts can rescue osteoclastogenesis in IKKalpha- and IKKbeta-defective mutant BM cells, exogenic TNFalpha can rescue only IKKalpha-deficient mutants, TNFR1 can rescue IKKbeta-deficient osteoclast progenitors, but not prevent TNFalpha-induced apoptosis, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | IKK is involved in NF-kappaB activation, IkappaB kinase IKKbeta, but not IKKalpha, is a critical mediator of NF-kappaB-dependent osteoclast survival preventing TNFalpha-induced cell death, and is required for formation of fully functional bone-resorbing osteoclasts and for inflammation-induced bone loss | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | - |
Mus musculus | - |
hematopoietic cell | - |
Mus musculus | - |
osteoblast | - |
Mus musculus | - |
osteoclast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | IKK is involved in NF-kappaB activation, IkappaB kinase IKKbeta, but not IKKalpha, is a critical mediator of NF-kappaB-dependent osteoclast survival preventing TNFalpha-induced cell death, and is required for formation of fully functional bone-resorbing osteoclasts and for inflammation-induced bone loss | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic NEMO/IKKgamma, complexes of IKKalpha and IKKgamma or IKKalpha homodimers are not stable | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
IKK | - |
Mus musculus |