KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics of IkappaB phosphorylation by parasite IKK, host NF-kappaB activation reveals a biphasic, hierarchical, and temporally regulated response | Toxoplasma gondii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
vacuolar membrane | parasitophorous, PVM | Toxoplasma gondii | 5774 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaB protein] | Toxoplasma gondii | parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex | ADP + [IkappaB phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | Mus musculus | required for activation of NF-kappaB resulting in activation of signalling pathways | ADP + [IkappaB phosphoprotein] | - |
? | |
additional information | Mus musculus | parasite Toxoplasma gondii IKKalpha, localized in parasitophorous vacuole membrane, activates the host intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Toxoplasma gondii | - |
RH strain in mouse embryonic fibroblast host MEF cells, wild-type and IKKalpha- or IKKbeta-deficient host cells | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MEF cell | wild-type and IKKalpha- or IKKbeta-deficient embryonic fibroblast cell line infected with parasite Toxoplasma gondii, RH strain | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [IkappaB protein] | - |
Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | - |
Toxoplasma gondii | ADP + [IkappaB phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex | Toxoplasma gondii | ADP + [IkappaB phosphoprotein] | - |
? | |
ATP + [IkappaB protein] | required for activation of NF-kappaB resulting in activation of signalling pathways | Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
additional information | parasite Toxoplasma gondii IKKalpha, localized in parasitophorous vacuole membrane, activates the host intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IKK | - |
Mus musculus |
IKK | - |
Toxoplasma gondii |
IKK complex | - |
Toxoplasma gondii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Toxoplasma gondii |